Web11 Nov 2009 · In 2001, a gene called FOXP2 was found to underlie a rare inherited speech and language disorder 1. It encodes a transcription factor called FOXP2, a protein 'dimmer … Forkhead box protein P2 (FOXP2) is a protein that, in humans, is encoded by the FOXP2 gene. FOXP2 is a member of the forkhead box family of transcription factors, proteins that regulate gene expression by binding to DNA. It is expressed in the brain, heart, lungs and digestive system. FOXP2 is found in many … See more As a FOX protein, FOXP2 contains a forkhead-box domain. In addition, it contains a polyglutamine tract, a zinc finger and a leucine zipper. The protein attaches to the DNA of other proteins and controls their activity through … See more The FOXP2 gene is highly conserved in mammals. The human gene differs from that in non-human primates by the substitution of two amino acids, a threonine to asparagine substitution at position 303 (T303N) and an asparagine to See more Chimpanzees In chimpanzees, FOXP2 differs from the human version by two amino acids. A study in Germany sequenced FOXP2's complementary DNA … See more • Chimpanzee genome project • Evolutionary linguistics • FOX proteins • Olduvai domain • Origin of language See more The FOXP2 gene has been implicated in several cognitive functions including; general brain development, language, and synaptic plasticity. The FOXP2 gene region acts as a transcription factor for the forkhead box P2 protein. Transcription factors affect other … See more FOXP2 is known to regulate CNTNAP2, CTBP1, SRPX2 and SCN3A. FOXP2 downregulates CNTNAP2, a member of the neurexin family found in neurons. CNTNAP2 … See more FOXP2 and its gene were discovered as a result of investigations on an English family known as the KE family, half of whom (15 … See more
Strategies for the Generation of Gene Modified Avian Models ...
WebFOXP2 gene [10] (see Box 1; Fig 1). The disorder in the KE family, and in an unrelated individual with a gross chromosomal rearrangement involving FOXP2, is confined to the … Web301 Moved Permanently. nginx otto sussman grant
Language fMRI abnormalities associated with FOXP2 gene …
Web13 Apr 2024 · We found that, like the language-related gene FOXP2, the executive function-related genes COMT, BDNF, and Kibra/WWC1 exhibited robust effects in both the language schema and lexical response phases, and modulated the brain–behavior relationships on language control. These findings point to a similar influence of the language-related gene … Web21 Jan 2024 · FOXP2 mutations cause a speech and language disorder, raising interest in potential roles of this gene in human evolution. A new study re-evaluates genomic … Web19 Feb 2013 · Back in 2001, the world of language research was rocked by the discovery that a gene called FOXP2 appeared to be essential for the production of speech. Researchers cautioned that FOXP2 is probably only one of many genes involved in human communication, but later discoveries seemed to underscore its importance. イグジスト 歌詞 考察