Rab7 heart
WebSenior scientist with more than 10 years of experience in infectious diseases research. Trained in Argentina in the University of Buenos Aires where I got my Ph.D. in biochemistry, focusing in the early interaction between arenavirus and its mammalian host cell. For my postdoctoral studies I joined Dr. Margaret Kielian’s lab in Albert Einstein College of … WebMar 21, 2024 · RAB7B (RAB7B, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB7B include Charcot-Marie-Tooth Disease, Axonal, Type 2B and Pontocerebellar Hypoplasia, Type 2E.Among its related pathways are Rab regulation of trafficking and Vesicle-mediated transport.Gene Ontology (GO) annotations related to this …
Rab7 heart
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WebEnter the email address you signed up with and we'll email you a reset link. WebConclusions These results suggest that rapid, Creg1-induced activation of autophagy is required to maintain heart function in the face of stress-induced myocardial damage. Both in vitro and in vivo studies identified that Creg1 deficiency reduced the expression of Rab7, thereby influencing the maturation of lysosomes and the formation of …
WebWild-type and RAB7 knockout samples were subjected to SDS-PAGE. ab137029 and ab8245 (loading control to GAPDH) were both diluted 1/1000 and incubated overnight at 4°C. Blots were developed with Goat anti-Rabbit IgG H&L (IRDye ® 800CW) preadsorbed ( ab216773 ) and Goat anti-Mouse IgG H&L (IRDye ® 680RD) preadsorbed ( ab216776 ) secondary … WebFigure 4. Gastrin inhibits Na+/H+ exchanger 3 (NHE3) expression via NHERF1 and NHERF2-mediated protein trafficking. A, Expressions of NHE3, NHERF1, NHERF2, NHERF3, ezrin, and IRBIT in intestinal brush border membranes of knockout (KO) mice and wild-type (WT) mice fed normal (N) or high (H) salt diet (n=4/group, *P<0.01 vs Cckbrfl/fl WT, 1-way ANOVA, …
WebMacropinocytosis plays an important role in the internalization of antigens by dendritic cells and is the route of entry for many bacterial pathogens; however, little is known about the molecular mechanisms that regulate the formation or maturation WebSep 19, 2024 · The interaction with Rab7 is mediated by an extended C-terminal WD40 domain that is present in WDR91, but not in its C. elegans orthologue SORF-1. Accordingly, endogenous WDR91 and its partner WDR81 in mammalian cells associate with endosomes in a Rab7-dependent manner, and WDR91 mutants that cannot bind Rab7 remain diffusely …
WebRAB7 is a small guanosine triphosphatase (GTPase) extensively studied as regulator of vesicular trafficking. Indeed, its role is fundamental in several steps of the late endocytic pathway, including endosome maturation, transport from early endosomes to late endosomes and lysosomes, clustering and fusion of late endosomes and lysosomes in …
WebThe lymphovascular embolus is an enigmatic entity adept at metastatic dissemination and chemotherapy resistance. Using MARY-X, a human breast cancer xenograft hyper discount aubervilliersWebApr 3, 2024 · heart, organ that serves as a pump to circulate the blood. It may be a straight tube, as in spiders and annelid worms, or a somewhat more elaborate structure with one or more receiving chambers (atria) and a main pumping chamber (ventricle), as in mollusks. In fishes the heart is a folded tube, with three or four enlarged areas that correspond to the … hyper discount herblayWebJan 17, 2014 · Rab7, Rab8B, and Rab24 have a key role in autophagosome maturation. ... Furthermore, extensive accumulation of autophagosomes was accompanied by minimal … hyper diseasesWebRab7 antibody detects Rab7 protein at cytoplasm in rat intestine by immunohistochemical analysis . Sample ... MCF7 (Lane 2), NIH/3T3 (Lane 3), HeLa (Lane 4), Mouse Heart (Lane 5), Rat Heart (Lane 6) were electrophoresed using NuPAGE™ 4-12% Bis-Tris Protein Gel (Product # NP0322BOX). Resolved proteins were then transferred onto a ... hyper-diseaseWebOct 1, 2024 · The specific subgroup of Rab7 in the mouse heart is highly expressed, and its deletion affects the signal transduction established on the anterior-posterior axis of the … hyperdirect pathway basal gangliahyper discount meuble mayotteWebOct 13, 2024 · The molecular machinery behind lysosome biogenesis and the maintenance of the perinuclear aggregate of late endocytic structures is not well understood. A likely candidate for being part of this machinery is the small GTPase Rab7, but it is unclear whether this protein is associated with lysosomes or plays any role in the regulation of the … hyper discount stores