WebSince hepatic metabolism is a saturable process, small increases in dosage can result in very large increases in serum levels. CYP2C9 also metabolizes warfarin and tolbutamide, which may explain interactions between phenytoin and these drugs. Phenytoin and metabolites may undergo enterohepatic recirculation prior to excretion. WebHLA-B Genotypes and Phenytoin Dosing: 2024 Update Jason H. Karnes1,2, ... dose must be lower in the setting of hepatic impairment. Careful dose adjustments must then be made to stabilize drug concentra-tions within the targeted therapeutic range (typically 10–20 mcg/ mL). In urgent situations, such as status epilepticus, intravenous
Phenytoin 100mg film-coated tablets - Summary of …
WebThe anticonvulsant phenytoin (5,5-diphenylhydantoin) provokes a skin rash in 5 to 10% of patients, which heralds the start of an idiosyncratic reaction that may result from covalent modification of normal self proteins by reactive drug metabolites. Phenytoin is metabolized by cytochrome P450 (P450) … Web1. aug 2024 · Phenytoin is an anti-seizure drug that has been under clinical evaluation for around eight decades. It is primarily used for the treatment of tonic-clonic and partial … the mussels k11 任食
Acute intermittent porphyria: Management - UpToDate
Web21. okt 2024 · Dosing in Patients with Renal or Hepatic Impairment or Hypoalbuminemia Because the fraction of unbound phenytoin is increased in patients with renal or hepatic disease, or in those with hypoalbuminemia, the monitoring of phenytoin serum levels should be based on the unbound fraction in those patients. Dosing in Geriatrics WebPrescribing advise for patients with hepatic impairment. Hepatotoxicity is either dose-related or unpredictable (idiosyncratic). Drugs that cause dose-related toxicity may do so at lower doses in the presence of hepatic impairment than in individuals with normal liver function, and some drugs that produce reactions of the idiosyncratic kind do so more frequently in … the mussel pot