WebJan 1, 2004 · We used the stable porcine granulosa cell line, JC-410, genetically modified to express a luciferase genomic construct carrying 2320 base pairs (bp) of the P450scc gene promoter (P450scc-2320-LUC). A construct containing only the luciferase gene, pOLUC, was used as a promoterless control. WebAlthough P450scc is required to produce placental progesterone required to maintain pregnancy, severe mutations in P450scc are compatible with term gestation; milder P450scc mutations may present later without disordered sexual development. Enlarged adrenals usually distinguish steroidogenic acute r …
Cholesterol Monooxygenase (Side Chain Cleaving) - an …
WebMay 18, 2001 · To optimize biodevice assembly and cholesterol sensing, recombinant and wild type P450scc cytochromes are extensively characterized both in solution and in thin solid films, using X-ray scattering, Brewster angle microscopy, quartz crystal nanobalance, ellipsometry, cyclic voltammetry, and circular dichroism. WebCytochrome cholesterol side-chain cleavage enzyme (P450scc) catalyzes the synthesis from cholesterol of sex hormones and other steroid hormones, e.g. estrogen, … mgp easy renter
C3151055[conceptid] - MedGen Result - National Center for …
WebDec 15, 2010 · P450scc is needed for placental progesterone production. Residual mutant P450scc activity seems to explain the term gestation in several cases of P450scc … Cholesterol side-chain cleavage enzyme is commonly referred to as P450scc, where "scc" is an acronym for side-chain cleavage. P450scc is a mitochondrial enzyme that catalyzes conversion of cholesterol to pregnenolone. This is the first reaction in the process of steroidogenesis in all mammalian … See more The highest level of the cholesterol side-chain cleavage system is found in the adrenal cortex and the corpus luteum. The system is also expressed at high levels in steroidogenic theca cells in the ovary, and Leydig cells in … See more P450scc catalyzes the conversion of cholesterol to pregnenolone in three monooxygenase reactions. These involve 2 See more Mutations in the CYP11A1 gene result in a steroid hormone deficiency, causing a minority of cases of the rare and potentially fatal condition lipoid congenital adrenal hyperplasia. Deficiency of CYP11A1 can result in hyperpigmentation, hypoglycemia, and … See more • Steroidogenic enzyme • Cytochrome P450 oxidase See more In each steroidogenic cell, the expression of the P450scc system proteins is regulated by the trophic hormonal system specific for the cell type. In adrenal cortex cells from zona fasciculata, the expression of the mRNAs encoding all three P450scc proteins is induced by See more Cholesterol side-chain cleavage enzyme inhibitors include aminoglutethimide, ketoconazole, and mitotane, among others. See more • Helmberg A (August 1993). "Twin genes and endocrine disease: CYP21 and CYP11B genes". Acta Endocrinologica. 129 (2): 97–108. doi:10.1530/acta.0.1290097. PMID 8372604. • Papadopoulos V, Amri H, Boujrad N, Cascio C, Culty M, … See more WebP450scc is the mitochondrial cholesterol side-chain cleavage enzyme catalyzing the series of reactions formerly termed 20,22-lyase. P450scc is encoded by CYP11A1 gene that is … how to calculate rolling sick pay