Klf2 activator
WebIn disease state, receptor activator of nuclear factor kappa-Β ligand (RANKL), an activator of osteoclasts, is elevated, whereas osteoclast inhibitor, osteoprotegrin (OPG) is reduced. The ratio of RANKL/OPG is modulated mainly by tumor necrosis factor (TNF) and interleukin-1 (IL-1) released from host cells, subsequently activating osteoclasts ... WebApr 25, 2006 · Mechanistically, KLF2 inhibits the transcriptional activity of both NF-κB and activator protein 1, in part by means of recruitment of transcriptional coactivator …
Klf2 activator
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WebNov 3, 2024 · Trichostatin D (TSD) was identified as a novel Krüppel-like factor 2 (KLF2) activator. (A) Proton and carbon nuclear magnetic resonance spectroscopy ( 1 H-NMR and 13 C-NMR) data of TSD. WebSW1353 cells were infected with nonspecific control virus (Lv-NC) or KLF2-expressing virus (Lv-KLF2) or incubated with the pharmacological KLF2 activator simvastatin (Sim). After 24 h, cells were treated with or without GGPP (GP, an inhibitor of KLF2) for 8 h prior to 24 h treatment with 20 ng/ml IL-1β. (a) Real-time PCR was performed to ...
WebApr 30, 2024 · KLF2 is known to be upregulated in response to shear stress and to induce activation of numerous downstream signaling pathways that exert protective effects against atherosclerosis [28, 29]. However, expression of KLF2 is flow-dependent, and OSS had been shown to induce transient upregulation of KLF2 followed by prolonged suppression [ 30 ]. WebNov 18, 2024 · Given the robust microglial response seen in K2KO mice, we believe that KLF2 serves to regulate aberrant activation of hypothalamic microglia, thereby protecting against centrally derived...
WebMar 4, 2024 · In an inflammatory response, high expression of KLF2 inhibited macrophage activation, while silencing KLF2 promoted macrophage activation and cytokine secretion … WebApr 1, 2024 · TL;DR: Results demonstrate that autophagy is an important mechanism related to Klfs in smooth muscle cells during AAA formation, and Chromatin immunoprecipitation assays demonstrated that Klf4, Klf2, and Zfp148 separately bind autophagic genes in smooth Muscle cells following elastase treatment. Abstract: Abdominal aortic aneurysms …
WebApr 13, 2024 · With regard to the positive role of mROS, but not of H 2 0 2, in certain inflammatory processes and with regard to ROS-mediated ERK5 activation, the Coon study about the activation of the MEK5/ERK5/KLF2 pathway by fluid shear stress-induced mtROS production has been added in the revised manuscript as suggested by the Reviewer …
WebMar 28, 2024 · KLF2 is a key regulator of activation, differentiation, and migration processes in numerous cell types, including endothelial cells function and vascular homeostasis . KLF2 plays a significant role in COVID-19 as SARS-CoV-2 significantly down-regulates KLF2 expression: COVID-19 patients have elevated serum levels of TNF-α and IL-1 and ... my plant\\u0027s leaves are turning yellowWebJul 12, 2024 · Previous studies have shown that KLF2 is a negative regulator of endothelial activation, dysfunction, and thrombosis. 37,38,39 KLF2 expression was downregulated by … the secret garden hunsburyWebJan 24, 2024 · Kruppel like factor 2 (KLF2) is a mechanosensitive transcription factor participating in the regulation of vascular endothelial cells metabolism. Activating KLF2 in endothelial cells induces eNOS … the secret garden inn and spa ncWebNov 25, 2010 · KLF2 was initially found in T cells to maintain the quiescent state of single-positive CD4 + or CD8 + T cells. 22, 25 KLF2 also inhibits Jurkat T-cell growth by inhibiting DNA synthesis. 29 Mechanistically, both activation and inhibitory domains of KLF2 are required to suppress Jurkat T-cell proliferation. my plantronics bluetooth won\u0027t connectWebJan 10, 2024 · Entrez Gene Summary for KLRF2 Gene. Enables protein homodimerization activity. Predicted to be involved in natural killer cell degranulation and positive regulation … my plant-based familyWebNov 18, 2024 · KLF2 regulated neutrophil activation in response to angiotensin II at the molecular level, partly through crosstalk with HIF1 signaling. Taken together, our data implicate neutrophil-mediated immunothrombotic dysregulation as a critical pathogenic mechanism leading to cardiac hypertrophy and heart failure. the secret garden hell\u0027s kitchenWebKLF2 orchestrates vascular homeostasis and serves as a key molecular switch between proinflammatory atheroprone and quiescent atheroresistant endothelial phenotype. This characteristic is attributed to its ability to activate atheroprotective and inhibit atherogenic endothelial transcription programs. my plantronics bluetooth stopped talking